Evidence Based Guideline: Heparin-Induced Thrombocytopenia (HIT)

Brief Description: Heparin-induced thrombocytopenia (HIT) is an immune-mediated reaction to heparin and platelet factor 4 (PF4) complexes resulting in a hypercoagulable state of platelet activation and thrombin generation. If left untreated, HIT carries a 30 – 50 % risk of life or limb-threatening thromboembolic complications. This guideline describes the development of heparin-induced thrombocytopenia along with several treatment options. A diagnostic algorithm is provided to aid in the diagnosis of the condition.