Evidence Based Guideline: Antibiotic Prophylaxis for Infective Endocarditis (IE)

Brief Description: Infective endocarditis (IE) is an infection of the endocardial surface of the heart that previously prompted widespread use of antimicrobial prophylaxis. However, existing evidence does not support the extensive use of antibiotic prophylaxis as it may lead to an increased risk of the development of multi-drug-resistant organisms, anaphylaxis, side effects of unnecessary antibiotic administration, and excessive costs to the health care system. This guideline provides information on conditions and procedures for when antibiotic prophylaxis is appropriate.