Mouse Model: B6.129X1(FVB) - Slc6a3tm1Hhg/J

Brief Description: DAT-CI mice contain the amino acid mutations L104V/F105C/A109V in exon 3 of the solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 (Slc6a3) gene. Slc6a3 encodes the dopamine transporter (DAT) which pumps the neurotransmitter dopamine out of the synapse back into cytosol. Dopamine release in the ventral tegmental area (VTA) plays a major role in reward-motivated behavior. Defects in dopamine transport reduces the rate of transport from the synapse, thus increasing the levels of dopamine in the brain. DAT has been implicated in a number of dopamine-related disorders, including attention deficit hyperactivity disorder, bipolar disorder, clinical depression, and alcoholism. 

Genetic Background

Allele Name: Targeted mutation 1 

Allele Type: Transgenic, (Hypomorph, Inserted expressed sequence)

Gene Symbol: Slc6a3, , solute carrier family 6 (neurotransmitter transporter, dopamine), member 3

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